UTA NURS 5334 Advanced Pharmacology Quiz 2 Study Guide with Clinical Pearls

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UTA NURS 5334 Advanced Pharmacology Quiz 2 Study Guide with Clinical Pearls Immunizations: Outline Notes IMMUNE AGENTS — IMMUNIZATIONS Advanced Pharmacology Comprehensive Outline II. Prevention of Infection: Foundations A. Importance of Vaccination Cornerstone of preventive disease control worldwide Greatest public-health intervention for reducing: Infectious disease burden Mortality, especially in children COVID-19 pandemic reinforced global reliance on vaccination B. Types of Immunization 1. Active Immunization Administration of antigen to stimulate host antibody production Induces immune memory Forms: Live-attenuated Inactivated Subunit Toxoid Recombinant Vector-based 2. Passive Immunization – exogenous antibody Administration of preformed antibodies Temporary protection Passive immunity from mom in newborns Used when: Immediate immunity needed Patient cannot mount immune response III. Active Immunity: Mechanisms & Principles - inoculation with all or part of modified product from microorganism evokes immune response A. Immune Response Characteristics Live-attenuated vaccines: Broader immunity Longer-lasting protection Inactivated vaccines: Require boosters B. Vaccine Schedules Children Birth–6 years 7–18 years Catch-up (4 months–18 years) Adults C. Environmental Influences on Immunity Research on environmental factors affecting immunity ongoing (e.g., PCBs and immune modulation) IV. ACIP General Vaccine Administration Guidelines Doses may be administered ±4 days from recommended date Live vaccines must be separated by Injection sites spaced Aspiration not required Re-immunization is not harmful Reduced dosing is never recommended Vaccine failure may result from: Improper storage Improper transport Accelerated schedules may be used for travel Absolute contraindication: prior anaphylaxis V. Inactivated Vaccines A. Diphtheria, Tetanus, Pertussis DTaP (acellular pertussis) Children

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