Test Bank for Advanced Health Assessment and Clinical Diagnosis in Primary Care, 5th Edition Authors; Joyce Dains Linda Baumann Pamela Scheibel

Advanced Health Assessment and Clinical Diagnosis in Primary Care, 5th Edition Authors; Joyce Dains Linda Baumann Pamela Scheibel

Chapter 2. Evidence-based health screening Multiple Choice Identify the choice that best completes the statement or answers the question. ____ 1. The first step in the genomic assessment of a patient is obtaining information regarding: A . Family history B. Environmental exposures C. Lifestyle and behaviors D . Current medications ____ 2. An affected individual who manifests symptoms of a particular condition through whom a family with a genetic disorder is ascertained is called a(n): A . Consultand B. Consulband C. Index patient D . Proband ____ 3. An autosomal dominant disorder involves the: A . X chromosome B. Y chromosome C. Mitochondrial DNA D . Non-sex chromosomes ____ 4. To illustrate a union between two second cousin family members in a pedigree, draw: A . Arrows pointing to the male and female B. Brackets around the male and female C. Double horizontal lines between the male and female D . Circles around the male and female ____ 5. To illustrate two family members in an adoptive relationship in a pedigree: A . Arrows are drawn pointing to the male and female B. Brackets are drawn around the male and female C. Double horizontal lines are drawn between the male and female D . Circles are drawn around the male and female ____ 6. When analyzing the pedigree for autosomal dominant disorders, it is common to see: A. Several generations of affected members B. Many consanguineous relationships C. More members of the maternal lineage affected than paternal D. More members of the paternal lineage affected than maternal ____ 7. In autosomal recessive (AR) disorders, individuals need: A . Only one mutated gene on the sex chromosomes to acquire the disease B. Only one mutated gene to acquire the disease C. Two mutated genes to acquire the disease D Two mutated genes to become carriers . ____ 8. In autosomal recessive disorders, carriers have: A . Two mutated genes; one from each parent that cause disease B. A mutation on a sex chromosome that causes a disease C. A single gene mutation that causes the disease D . One copy of a gene mutation but not the disease ____ 9. With an autosomal recessive disorder, it is important that parents understand that if they both carry a mutation, the following are the risks to each of their offspring (each pregnancy): A . 50% chance that offspring will carry the disease B. 10% chance of offspring affected by disease C. 25% chance children will carry the disease D . 10% chance children will be disease free ____ 10. A woman with an X-linked dominant disorder will: A . Not be affected by the disorder herself B. Transmit the disorder to 50 % of her offspring (male or female) C. Not transmit the disorder to her daughters D . Transmit the disorder to only her daughters ____ 11. In creating your female patient’s pedigree, you note that she and both of her sisters were affected by the same genetic disorder. Although neither of her parents had indications of the disorder, her paternal grandmother and her paternal grandmother’s two sisters were affected by the same condition. This pattern suggests: A . Autosomal dominant disorder B. Chromosomal disorder C. Mitochondrial DNA disorder D . X-linked dominant disorder ____ 12. A woman affected with an X-linked recessive disorder: A . Has one X chromosome affected by the mutation B. Will transmit the disorder to all of her children C. Will transmit the disorder to all of her sons D . Will not transmit the mutation to any of her daughters ____ 13. Which of the following are found in an individual with aneuploidy? A . An abnormal number of chromosomes B. An X-linked disorder C. Select cells containing abnormal-appearing chromosomes D . An autosomal recessive disorder ____ 14. The pedigree of a family with a mitochondrial DNA disorder is unique in that: A . None of the female offspring will have the disease B. All offspring from an affected female will have disease C. None of the offspring of an affected female will have the disease D . All the offspring from an affected male will have disease ____ 15. Which population is at highest risk for the occurrence of aneuploidy in offspring?