(Questions and Answers) SSRIs (Selective-Serotonin Reuptake Inhibitors) NCLEX EXAM 2026

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(Questions and Answers) SSRIs (Selective-Serotonin Reuptake Inhibitors)

1. Which statement below best describes the mechanism of action of how SSRIs work?

A. “SSRIs inhibit the reuptake of GABA by blocking the reuptake of serotonin from the pre-synaptic neuron.”

B. “SSRIs enhance the reuptake of GABA by amplifying the action of the serotonin receptors found on the post-synaptic neuron.”

C. “SSRIs inhibit the reuptake of the neurotransmitter serotonin by the pre-synaptic neuron.”

D. “SSRIs enhance the reuptake of serotonin by the receptors on the post-synaptic neuron.”

The answer is C. SSRIs (selective serotonin reuptake inhibitors) inhibit the reuptake of the neurotransmitter serotonin by the pre-synaptic neuron. It does this by blocking the serotonin-transporter protein (SERT).

2. The physician determines a patient needs to be started on a selective serotonin reuptake inhibitor (SSRI). As the nurse, you know which medication below is NOT an SSRI?

A. Citalopram

B Paroxetine

C. Fluoxetine

D. Rasagiline

The answer is D. Rasagiline is a MAOI (monoamine oxidase inhibitor) and is used to treat Parkinson’s Disease.

3. Fill in the blank: After the pre-synaptic neuron releases serotonin, it enters the _______________ and some of the serotonin binds with receptors found on the post-synaptic neuron. The serotonin that did not bind with a receptor is removed from this space via a protein serotonin-transporter back into the ________________ for future use.

A. synaptic vesicle; pre-synaptic neuron

B. synaptic cleft; post-synaptic neuron

C. axon terminal; pre-synaptic neuron

D. synaptic cleft; pre-synaptic neuron

The answer is D. After the pre-synaptic neuron releases serotonin, it enters the SYNAPTIC CLEFT and some of the serotonin binds with receptors found on the post-synaptic neuron. The serotonin that did not bind with a receptor is removed from this space via a protein serotonin-transporter back into the PRE-SYNAPTIC NEURON for further use.

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