Chapter 02 Multiple Choice Identify the choice that best completes the statement or answers the question. ____ 1. Research that directly takes knowledge from bench to bedside is known as? a. The scientific method c. Evidence-based practice b. Basic research d. Translational research ____ 2. A study that attempts to be more generalizable to practice than research settings is known as a(n): a. Efficacy study c. Randomized trial b. Effectiveness study d. Translational research ____ 3. Efficacy research utilizes all of the following except? a. Human subjects c. Broad treatment protocols b. Random assignment to groups d. Strict inclusion and exclusion criteria ____ 4. Which of the following is an example of an efficacy study? a. Randomized controlled trial c. Clinical effectiveness research b. Observational research d. Outcomes research ____ 5. A translational research study that translates research evidence to practice is classified in which translation block? a. T1 c. T3 b. T2 d. T4 ____ 6. A T2 translational study focuses on translation to which of the following blocks? a. Humans c. Patients b. Populations d. Practice ____ 7. Comparative effectiveness studies generally include all of the following except? a. A control group c. Flexible protocols b. Few exclusion criteria d. Diverse treatment settings ____ 8. Studies that focus on the impact of results of health care practices and interventions are known as? a. Implementation research c. Efficacy research b. Outcomes research d. Translational research ____ 9. Which of the following is concerned with studying the methods of how research evidence is adopted into clinical practice? a. Implementation research c. Efficacy research b. Outcomes research d. Translational research ____ 10. Which of the following best describes the use of patient-reported outcome measures (PROM) in pragmatic trials? a. They do not correlate with movement b. They measure things that a patient may care about c. They are not reliable d. They measure changes in the disease-status Chapter 02 Answer Section MULTIPLE CHOICE 1. ANS: D Rationale: Translational research refers to the direct application of scientific discoveries into clinical practice. DIF: Easy OBJ: 1 2. ANS: B Rationale: Effectiveness studies are conducted in real-world conditions as compared to the ideal conditions of efficacy studies, such as randomized trials. This makes them more generalizable to clinical practice. Translational research may include both efficacy and effectiveness studies. DIF: [Difficulty level] OBJ: 2 3. ANS: C Rationale: Efficacy research will have specific well-defined treatment protocols in order to investigate a cause and effect relationship. Broad treatment protocols are found more frequently in effectiveness studies. Although broad treatment protocols may be more reflective of clinical practice, they may introduce bias in determining if the treatment caused the outcome. DIF: Easy OBJ: 2,3 4. ANS: A Rationale: A randomized trial attempts to minimize potential sources of bias and is considered an efficacy study. The other options are examples of effectiveness studies. DIF: Easy OBJ: 2 5. ANS: C Rationale: T3 studies translate evidence to practice to asses if a treatment will work in real-world conditions. See figure 2-1 for more information. DIF: Easy OBJ: 4 6. ANS: C Rationale: A T2 study frequently utilized randomized controlled trials to demonstrate a treatment can work with patients under ideal-conditions. T1 focuses on translation to humans to show a treatment can work. A T3 study is concerned with translation to practice and the focus of a T4 study is populations. DIF: Moderate OBJ: 4
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