NU 636 QUIZ 5 questions and answers 2023

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NU 636 QUIZ 5 questions and answers 2023 Week 5 What pharmacologic agents are currently recommended for the treatment of GERD? Antacids Antacids relieve heartburn (indigestion). They work by changing the stomach acid that causes heartburn. Common OTC antacids include: • Mylanta • Rolaids • Tums Histamine-2 (H2) blockers H2 blockers relieve and prevent heartburn and work by reducing the amount of acid produced by the stomach. Typically, they start to work within one to three hours and provide acid-suppression for several hours. Because acid reducers may interact with certain other medicines, ask your doctor or pharmacist before use if you are taking a prescription drug. Common OTC H2-blockers include: • Tagamet HB (cimetidine) • Pepcid Complete or Pepcid AC (famotidine) • Axid AR (nizatidine) Proton pump inhibitors (PPIs) OTC PPIs treat frequent heartburn (occurs 2 or more days a week) and are not intended for immediate relief of heartburn, as they may take one to four days for full effect. In contrast, prescription PPIs are used to treat conditions like gastroesophageal reflux disease (GERD), stomach and small intestine ulcers, and inflammation of the esophagus. PPIs work by reducing the amount of acid produced by the stomach. Because acid reducers may interact with certain other medicines, ask your doctor or pharmacist before use if you are taking a prescription drug. OTC PPIs are only intended for a 14-day course of treatment and can be used up to three times per year. • Prevacid 24HR (lansoprazole) • Nexium 24HR (esomeprazole) • Prilosec OTC (omeprazole magnesium) • Zegerid OTC (omeprazole and sodium bicarbonate) - What are the pharmacologic regimens for treatment of H-pylori? RECOMMENDED Clarithromycin triple therapy consists of a PPI, clarithromycin (Biaxin), and amoxicillin or metronidazole (Flagyl) for 14 days. The effect of H. pylori resistance to clarithromycin is well documented. Clarithromycin should be avoided in locations where resistance is greater than 15% and in patients with any previous macrolide exposure. Bismuth quadruple therapy consists of a PPI, bismuth, tetracycline, and a nitroimidazole for 10 to 14 days. It may be a particularly good option in patients with macrolide exposure or who are allergic to penicillin. Although metronidazole resistance impacts the effectiveness of this regimen, it is not nearly as profound as with clarithromycin triple therapy. Bismuth quadruple

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