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Hesi A2 Biology Study Guide with Practice Questions

Hesi A2 Biology Study Guide with Practice Questions

Hesi A2 Biology Study Guide with Practice Questions

Last updated 23 July 2025

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If you're preparing for the HESI A2 Biology section, you're in the right place. This collection features real exam-style questions from Versions 1 and 2 of the test, giving you a realistic look at the types of concepts and wording you’ll face on exam day. From cell structures and organelles to transport mechanisms, photosynthesis, and cell division, these questions cover all the high-yield topics.

Use this guide to quiz yourself, check your weak spots, and reinforce your understanding before test day. Whether you're aiming for a competitive nursing program or just want to feel confident walking into the exam, this is the biology prep you need.

In this HESI A2 Biology study guide, you will find a collection of real exam-style questions from Versions 1 and 2 of the test. By revising using this study material, students will have a chance to get a realistic look at the types of concepts and topics commonly examined. From cell structures and organelles to transport mechanisms, photosynthesis, and cell division, these questions cover all the high-yield topics.

It is advised to use this guide as a hallmark to quizing yourself, finding areas that you have weakness.

Download: HESI A2 Biology Real Exam Version 1 and 2

Hesi A2 Biology Practice Questions 

1. Which movement requires carrier protein but noo direct cellular energy?

Facilitated transport

2. Which term denotes the movement of glucose molecules from an area of lower concentration to an area of higher concentreation?

Active transport

3. Plasmolysis is a term describing?

Cellular shrinkage, which occurs when cells are immersed in hypertonic solurion

4. The movement of substances from lesser concentration to higher concentration is called?

Active transport

5. Which particular structure is present in both eucaryotic and prokaryotic cells?

Cell membrane

6. Plant cells differ from animal cells in?

The plant cells have a cell wall and animal cells do not

7. Which cell type is characterized by the lack of true nucleus and the absence of membrane-bound organelle?

Prokaryotic cell

8. Which organelle is associated with hydrolytic enzymes and is sometimes reffered to as a “suicide bag”

Lysosomes

Related free study materials: Hesi Case studies-Pediatric Cystic Fibrosis and Traumatic Brain Injury Study Guide

9. Pinocytosis is the process of?

Enclosing a liquid substance in a membrane and secreting it into the cell

10. The plasma membrane of the eurokaryotic cell determines selectively which substances can enter and leave the cell. Such a membrane is said to be ?

Selectively permeable

11. What primarily determines the shape of cells that lack cell walls?

Microtubule and microfilaments

12. Which pair of organelles is responsible foe energy supply to eurokaryotic cells?

Chloroplast and mitochondria

13. Whit which organelle is the synthesis of ATP associated?

Mitochondrion

14. The plasma membrane is soluble to?

Lipids

15. The process whereby muscle cell produce lactic acid is called?

Fermentation

16. During aerobic respiration, which one of the following substances is released?

ATP

17. Noncyclic-photophosphorylation takes place inside the?

Thylakoids

18. The dark reaction of photosynthesis takes place in ?

Ribosomes

57. In eukaryotic cells, the phase of division that produces two daughter cells is ?

Cytokinesis

58. Some substances are transported across cell membranes by proteins known as ?

Permeases

59. The cellular organelle where respiratory reactions for the release of energy occurs is a ?

Mitochondrion

60. The most efficient cellular respiratiry process, in terms of energyyield per molecule of glucose, is ?

Aerobic respiration

61. A cellular organelle found in typical plant cells but not in typical animal cells is the ?

Chloroplast

62. Every cell contains ?

A cell membrane and cytoplasm

63. The two organic substances present in chromosomes are ?

Protein and nucleic acid

64. Genes may be defined as ?

Functional segments of chromosomes

65. The dense mass of ribonucleic acid found within the nucleus is the ?

Nucleolus

66. The endoplasmic reticulum may be described as a ?

Series of membranes in the cell’s cytoplasm

67. The lysosomes of a cell contain many ?

Digestive enzyme

68. The mitochondria of the cell are best known as the organelles where ?

Energy is released from food molecules

69. The flagella of human cells cause ?

Cell movement

70. During the process of ............... Molecules moves from a region of high concentrarion to one of low concentration

diffusion 

71. The plasma membrane is a semipermeable membrane because it ?

Lets only certain molecules through

72. In active transport, chemical substances move from a region of low concentrationto one of high concentration, and therefore they require ?

An expediture of energy

73. Phagocytosis is a form of endocytosis in which?

The cell takes particulate matter into itself

Need a refresher? Review core concepts in our HESI Biology Study Guide

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