erythropoiesis erythropoietin red blood cells hemoglobin reticulocytes iron deficiency anemia sideroblastic anemia thalassemia macrocytic anemia vitamin b12 deficiency folate deficiency pernicious anemia aplastic anemia hemolytic anemia g6pd deficiency anemia of chronic disease ferritin transferrin tibc inflammation complement system coagulation system kinin system histamine macrophages neutrophils eosinophils basophils mast cells lymphocytes natural killer cells b cells t cells innate immunity adaptive immunity primary immune response secondary immune response infection process endemic epidemic pandemic exotoxins endotoxins general adaptation syndrome stress response hiv pathophysiology aids abo blood groups rh system alloimmunity graft rejection immunodeficiency hypersensitivity reactions advanced nursing practice pathophysiology evidence based practice patient centered care health promotion clinical decision making