Share this study material
Test Bank for Clinical Calculations 9th Edition by LeFever Kee
Chapter 07: Methods of Calculation for Individualized Drug Dosing
Kee: Clinical Calculations: With Applications to General and Specialty Areas, 9th Edition
OTHER
Body Surface Area by Square Root
1. Order: cyclophosphamide 500 mg/m2 in 500 mL of normal saline solution (NSS) over 90 minutes Patient height and weight: 5 ft 10 in, 142 lb
Drug available: cyclophosphamide 100 mg dilute with 5 mL of sterile water; yields 20 mg/mL a. What is the patient’s body surface area (BSA) (m2)?
b. What is the total dose?
c. How many milliliters should you prepare?
ANS:
a. 
= 1.78m2
b. 500 mg/m2 × 1.78 m2 = 890 mg
c. FE: 890 mg/100 mg × 5 mL = 44.5 mL
OR
D 890mg
BF: H × V = 
100mg × 5mL = 44.5mL
2. Order: cisplatin 50 mg/m2 in 500 mL of NSS intravenously over 90 minutes
Patient height and weight: 5 ft 6 in, 160 lb Drug available: cisplatin 100 mg/100 mL a. What is the patient’s BSA (m2)?
b. What is the total dose?
c. How many milliliters should you prepare?
ANS:
a. 
= 1.84m2
b. 50 mg × 1.84 m2 = 92 mg
c. FE: 92 mg/100 mg × 100 mL = 92 mL
OR
D 92mg
BF: H × V = 100mg × 100mL = 92mL
3.
Give dacarbazine 250 mg/m2/day × 5 days.
Patient height: 5 ft 10 in
Patient weight: 173 lb What is the daily dose with a. square root method?
b. nomogram?
ANS:
a. 
3.8677 = 1.97m2
250 mg/m2/day × 1.97 m2 = 493 mg/day
b. Height 70 in, weight 173 lb, intersects 2.02 m2 250 mg/m2/day × 2.02 m2 = 505 ≈ 500 mg/day
4.
Give 5-fluorouracil 450 mg/m2/wk.
Patient height: 5 ft 6 in
Patient weight: 210 lb What is the weekly dose with a. square root method?
b. nomogram?
ANS:
a. 
4.43 = 2.10m2
450 mg/m2/wk × 2.10 m2 = 945 mg/wk
b. Height 66 in, weight 210 lb, intersects 2.04 m2 450 mg/m2/wk × 2.04 m2 = 918 ≈ 920 mg/wk
5.
Give leucovorin 200 mg/m2/wk.
Patient height: 5 ft 6 in
Patient weight: 210 lb What is the weekly dose with a. square root method?
b. nomogram?
ANS:
a. 4.43 = 2.10m2
200 mg/m2/wk × 2.10 m2 = 420 mg/wk
b. Height 66 in, weight 210 lb, intersects 2.04 m2 200 mg/m2/wk × 2.04 m2 = 408.00 ≈ 400 mg/wk
6.
Give cisplatin 30 mg/m2/day × 3 days.
Patient height: 70 in
Patient weight: 80 kg What is the daily dose with a. square root method?
b. nomogram?
ANS:
a. 80 kg × 2.2 = 176 lb
3.93 = 1.98m2 30 mg/m2/day × 1.98 m2 = 59.4 ≈ 59 mg/day
b. Height 70 in, weight 80 kg, intersects 2.08 m2 30 mg/m2/day × 2.08 m2 = 62.4 ≈ 62 mg/day
7.
Give cisplatinum 80 mg/m2/wk.
Patient height: 6 ft 2 in
Patient weight: 186 lb What is the weekly dose with a. square root method?
b. nomogram?
ANS:
a. 
4.39 = 2.09m2
80 mg/m2/wk × 2.09 m2 = 167.2 mg/wk
b. Height 74 in, weight 186 lb, intersects 2.10 m2 80 mg/m2/wk × 2.10 m2 = 168 ≈ 170 mg/wk
8.
Give etoposide 120 mg/m2/wk.
Patient height: 74 in
Patient weight: 70 kg What is the weekly dose with a. square root method?
b. nomogram?
ANS:
a. 70 kg × 2.2 = 154 lb
3.639 = 1.91m2
120 mg/m2/wk × 1.91 m2 = 229.2 mg/wk
b. Height 74 in, weight 70 kg, intersects 2.06 m2 120 mg/m2/wk × 2.06 m2 = 247.2 ≈ 250 mg/wk
9.
Give Cytoxan 600 mg/m2/wk. Patient height: 70 in
Patient weight: 85 kg What is the weekly dose with a. square root method?
b. nomogram?
ANS:
a. 85 kg × 2.2 = 187 lb
4.18 = 2.04m2
600 mg/m2/wk × 2.04 m2 = 1224 or 1225 mg/wk b. Height 70 in, weight 85 kg, intersects 2.08 m2 600 mg/m2/wk × 2.08 m2 = 1248 ≈ 1250 mg/wk
10.
Give Adriamycin 60 mg/m2/wk.
Patient height: 70 in
Patient weight: 80 kg What is the weekly dose with a. square root method?
b. nomogram?
ANS:
a. 80 kg × 2.2 = 176 lb
3.93 = 1.98m2
60 mg/m2/wk × 1.98 m2 = 118.8 mg/wk = 119 mg/wk b. Height 70 in, weight 80 kg, intersects 2.04 m2 60 mg/m2/wk × 2.04 m2 = 122.4 mg/wk
11. For the following questions, use the square root method and/or nomogram. Note discrepancies between methods.
Give vincristine 2 mg/m2/week.
Patient height: 62 in
Patient weight: 75 kg What is the weekly dose with a. square root method?
b. nomogram?
ANS:
a. 75 kg × 2.2 = 165 lb
3.27 = 1.81m2
2 mg/m2/wk × 1.81 m2 = 3.62 = 3.6 mg/wk
b. Height 62 in, weight 75 kg, intersects 1.78 m2 2 mg/m2/wk × 1.78 m2 = 3.56 ≈ 3.6 mg/wk
12.
Give mitomycin 15 mg/m2/week.
Patient height: 65 in
Patient weight: 64 kg What is the weekly dose with a. square root method?
b. nomogram?
ANS:
a. 64 kg × 2.2 = 140.8 or 141 lb
2.93 = 1.71m2
15 mg/m2/wk × 1.71 m2 = 25.6 or 26 mg/wk
b. Height 65 in, weight 64 kg, intersects 1.75 m2 15 mg/m2/wk × 1.75 m2 = 26.25 ≈ 26 mg/wk
13. For the following questions, use the square root method and/or nomogram. Note discrepancies between methods.
Give mitoxantrone 12 mg/m2/day × 3 days.
Patient height: 5 ft 8 in
Patient weight: 150 lb What is the daily dose with a. square root method?
b. nomogram?
ANS:
a. 
3.25 = 1.8m2
12 mg/m2/day × 1.80 m2 = 21.6 or 22 mg/day
b. Height 68 in, weight 150 lb, intersects 1.85 m2 12 mg/m2/day × 1.85 m2 = 22.2 ≈ 22 mg/day
14.
Give cytosine arabinoside 100 mg/m2/day × 7 days.
Patient height: 5 ft 2 in
Patient weight: 130 lb What is the weekly dose with a. square root method?
b. nomogram?
ANS:
a. 
2.57 = 1.6m2
100 mg/m2/day × 1.6 m2 = 160 mg/day
b. Height 62 in, weight 130 lb, intersects 1.65 m2 100 mg/m2/day × 1.65 m2 = 165 mg/day
15. For the following questions, use the square root method and/or nomogram. Note discrepancies between methods.
Give methotrexate 3.3 mg/m2/day × 7 days.
Patient height: 72 in
Patient weight: 82 kg What is the daily dose with a. square root method?
b. nomogram?
ANS:
a. 82 kg × 2.2 = 180.4 lb
4.15 = 2.04m2
3.3 mg/m2/day × 2.04 m2 = 6.7 mg/day
b. Height 72 in, weight 82 kg, intersects 2.10 m2 3.3 mg/m2/day × 2.10 m2 = 6.93 ≈ 6.9 mg/day
16. For the following questions, use the square root method and/or nomogram. Note discrepancies between methods.
Give prednisone 60 mg/m2/day × 7 days.
Patient height: 72 in
Patient weight: 84 kg What is the daily dose with a. square root method?
b. nomogram?
ANS:
a. 84 kg × 2.2 = 184.8 or 185 lb
4.25 = 2.06m2
60 mg/m2/day × 2.06 m2 = 123.6 or 124 mg/day
b. Height 72 in, weight 84 kg, intersects 2.10 m2
60 mg/m2/day × 2.10 m2 = 126 mg/day
17. For the following questions, use the square root method and/or nomogram. Note discrepancies between methods.
Give idarubicin hydrochloride 12 mg/m2/day × 3 days.
Patient height: 60 in
Patient weight: 60 kg What is the daily dose with a. square root method?
b. nomogram?
ANS:
a. 60 kg × 2.2 = 132 lb
2.53 = 1.59m2
12 mg/m2/day × 1.59 m2 = 19.1 or 19 mg/day
b. Height 60 in, weight 60 kg, intersects 1.60 m2 12 mg/m2/day × 1.60 m2 = 19.2 ≈ 19 mg/day
18. For the following questions, use the square root method and/or nomogram. Note discrepancies between methods.
Give cytarabine 100 mg/m2/day × 7 days.
Patient height: 64 in
Patient weight: 65 kg What is the daily dose with a. square root method?
b. nomogram?
ANS:
a. 65 kg × 2.2 = 143 lb
2.92 = 1.71m2
100 mg/m2/day × 1.71 m2 = 171 mg/day
b. Height 64 in, weight 60 kg, intersects 1.69 m2
100 mg/m2/day × 1.69 m2 = 169 ≈ 170 mg/day
19. Order: streptozocin 1000 mg/m2 in 100 mL D5W over 2 hours
Patient’s height and weight: 5 ft 2 in and 210 lb
Drug available: streptozocin 1 g powdered vial, reconstitute with 9.5 mL NS; yields 100 mg/mL a. What is the patient’s BSA (m2)?
b. What is the total dose?
c. How many milliliters should you prepare?
ANS:
a. 
4.16 = 2.04m2
b. 2.04 m2 × 1000 mg/m2 = 2040 mg
c. 
BF: DH × V = 1002040mg×mg1mL = 20.4mL
20. Order: methotrexate 3 mg/m2 PO × 2 weekly Patient’s height and weight: 5 ft 2 in and 130 lb Drug available: methotrexate tablets 2.5, 5, 7.5 mg a. What is the patient’s BSA (m2)?
b. What is the total dose?
ANS:
a. 
2.57 = 1.60m2
b. 1.6 m2 × 3 mg/m2 = 4.8 mg or 5 mg tablet twice a week
21. Order: sargramostim 250 mcg/m2/day, dilute in 50 mL and infuse over 2 hours
Patient’s height and weight: 5 ft 10 in and 285 lb Drug available: sargramostim 500 mcg/mL a. What is the patient’s BSA (m2)?
b. What is the total dose?
c. How many milliliters should you prepare?
ANS:
a. 
6.37 = 2.52m2
b. 2.52 m2 × 250 mcg/m2 = 630 mcg
630mcg
c. 
500mcg × 1mL = 1.26mL
22. Order: clofarabine 52 mg/m2 daily and infuse in 250 mL D5W over 2 hours
Patient’s height and weight: 5 ft 4 in and 115 lb
Drug available: 20 mg/20 mL
a. What is the patient’s BSA (m2)?
b. What is the total dose?
c. How many milliliters should you prepare?
ANS:
a. 
2.35 = 1.53m2
b. 1.53 m2 × 52 mg/m2 = 79.56 or 80 mg
80mcg
c. 20mcg × 20mL = 80mL
Contact the Author
Please Sign In to contact this author.
