What is Modified Release?
The term modified-release is used to describe dosage forms that alter the timing and/or
the rate of release of a conventional drug product/dosage form
- FDA does define this
Some Modified Release Systems
- some of these have overlap
1. Delayed release
2. Repeated Release or Repeat Action
4. Extended, Sustained, Long-Acting, Prolonged, Controlled Release
5. Targeted Release
Delayed-release
- dosage forms release the drug at a later time than an immediate dose system
- Delayed-release can include enteric-coated tablets, where timed release is achieved
by a barrier coating
- takes more time to release drug; doesn't start dissolving until a certain point of time
Repeat-release
- multiple doses of immediate release drug units with intermittent dosing
- Such as repeat-action tablets and capsules
Extended, Sustained, Long-Acting, Prolonged, Controlled Release
- Extended, Sustained-release systems slowly release the drug over an extended period
of time
- Rate and duration are not always designed to a particular profile
- If the system can maintain predictable levels of drug in the target tissue or cells, it is
considered controlled- release. (Examples: XL,SR,CR)
- Controlled release systems are also called extended or sustained (prolonged) release
- dissolves and continues dissolving for a longer time