Heparin NCLEX Questions (Anticoagulation) NCLEX EXAM 2022

1. Heparin is an anticoagulant. What family of anticoagulant medications does this drug belong to?

A. Direct thrombin inhibitors

B. Indirect thrombin inhibitors

C. Vitamin K antagonists

D. Factor Xa inhibitors

The answer is B. Heparin is an anticoagulant that belongs to the Indirect Thrombin Inhibitors family.

2. Which statement below BEST describes how Heparin works as an anticoagulant?

A. “It inhibits clotting factors from synthesizing Vitamin K.”

B. “It inactivates the extrinsic pathways of coagulation.”

C. “It prevents Factor Xa from activating prothrombin to fibrinogen.”

D. “It enhances the activation of antihrombin III, which prevents the activation of thrombin and the conversion of fibrinogen to fibrin.”

The answer is D. Heparin enhances the activation of antihrombin III, which prevents the activation of thrombin and the conversion of fibrinogen to fibrin. Therefore, this medication INDIRECTLY inhibits thrombin via antithrombin III.

3. Which patients below would be at a HIGH risk for developing adverse effects of Heparin drug therapy? Select all that apply:

A. A 55-year-old male patient who is post-op day 1 from brain surgery.

B. A 45-year-old female patient with a pulmonary embolism.

C. A 36-year-old male patient with active peptic ulcer disease.

D. A 43-year-old female with uncontrolled atrial fibrillation.

The answers are A and C. These patients are both at risk for major bleeding if placed 

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